| Assay ID | Title | Year | Journal | Article |
|---|
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1574419 | Agonist activity at Hsp70 in HEK293 cells expressing CFTR F508del mutant (unknown origin) assessed as increase in steady-state levels of CFTR mutant at 30 uM in presence of Hsp70 antagonist MAL3-101 after 24 hrs by immunoblot assay | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574412 | Agonist activity at Hsp40-stimulated yeast Hsp70 Ssa1 assessed as increase in Ssa1-mediated ATP hydrolysis at 100 uM preincubated for 5 mins followed by alpha-32P ATP addition and measured at 15 mins intervals for 1 hr by phosphorimaging analysis | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574416 | Agonist activity at Hsp70 in HEK293 cells expressing CFTR F508del mutant (unknown origin) assessed as increase in steady-state levels of CFTR mutant at 30 uM after 24 hrs by immunoblot assay | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1655905 | Agonist activity at HSP70 in human HEK293H cells transfected with HTT17Q assessed as reduction in HTT protein aggregation at 10 uM measured after 6 hrs by DAPI staining based confocal microscopy | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| Synthesis and Selective Functionalization of Thiadiazine 1,1-Dioxides with Efficacy in a Model of Huntington's Disease. |
| AID1574413 | Agonist activity at unfolded peptide CMLA-stimulated yeast Hsp70 Ssa1 assessed as increase in Ssa1-mediated ATP hydrolysis preincubated for 5 mins followed by alpha-32P ATP addition and measured at 15 min intervals for 1 hr by phosphorimaging analysis bas | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574414 | Agonist activity at Hsp70 in human H4 cells expressing wild type alpha-synuclein (unknown origin) assessed as inhibition of alpha-synuclein aggregation by measuring increase in cells lacking alpha-synuclein inclusions at 100 uM after 24 hrs by epifluoresc | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574421 | Cytotoxicity against HEK293H cells after 24 hrs by CellTiter-Glo assay | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574424 | Cytotoxicity against human MCF7 cells assessed as cell viability at 100 uM after 24 hrs by CellTiter-Glo assay | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1879924 | Modulation of F508del-CFTR mutant transfected in human HEK293 cells assessed as fold increase in level of ER glycosylated form of F508del-CFTR at 30 uM treated for 24 hrs by immunoblot assay | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7
| Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives. |
| AID1574423 | Cytotoxicity against human MCF7 cells after 24 hrs by CellTiter-Glo assay | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574426 | Induction of heat shock response in human H4 cells assessed as increase in DNAJB1 expression at 100 uM after 24 hrs by RT-PCR analysis relative to 18S RNA | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574433 | Agonist activity at Hsp70 in human H4 cells expressing wild type alpha-synuclein (unknown origin) assessed as inhibition of alpha-synuclein aggregation by measuring decrease in percentage of cells displaying 1 to 5 alpha-synuclein inclusions at 100 uM aft | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574431 | Agonist activity at Hsp40-stimulated yeast Hsp70 Ssa1 assessed as turnover rate for increase in Ssa1-mediated ATP hydrolysis at 100 uM preincubated for 5 mins followed by alpha-32P ATP addition and measured at 15 mins intervals for 1 hr by phosphorimaging | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574425 | Induction of heat shock response in human H4 cells assessed as increase in HSPA1A expression at 100 uM after 24 hrs by RT-PCR analysis relative to 18S RNA | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574422 | Cytotoxicity against HEK293H cells assessed as cell viability at 100 uM after 24 hrs by CellTiter-Glo assay | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574430 | Induction of heat shock response in human H4 cells assessed as increase in BiP expression at 100 uM after 24 hrs by RT-PCR analysis relative to 18S RNA | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574415 | Agonist activity at Hsp70 in human H4 cells expressing wild type alpha-synuclein (unknown origin) assessed as inhibition of alpha-synuclein aggregation by measuring decrease in Triton X-100-insoluble alpha-synuclein in cells at 100 uM after 24 hrs by immu | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574432 | Agonist activity at yeast Hsp70 Ssa1 assessed as increase in Ssa1-mediated ATP hydrolysis preincubated for 5 mins followed by alpha-32P ATP addition and measured at 15 min intervals for 1 hr by phosphorimaging analysis based single-turnover assay | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| AID1574434 | Cytotoxicity against human H4 cells expressing wild type alpha-synuclein (unknown origin) assessed as reduction in cell viability after 24 hrs by CellTiter-Glo assay | 2019 | Bioorganic & medicinal chemistry, 01-01, Volume: 27, Issue:1
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |